个人简介

吕优优，男，博士，中共党员。省级人才项目-“湖北省青年科技人才晨光托举工程(A类)”获得者，环境食品学教育部重点实验室固定成员，担任AG真人国际青年联合会第三届委员会委员，中国食品科学技术学会会员，湖北省食品科学技术学会会员，研究方向为功能性乳品与益生乳酸菌工程，指导多位员工获得国家/省/校级竞赛奖项及省级科研创新训练项目。作为负责人主持“国家自然科学基金”“湖北省自然科学基金”“湖北省人才项目”“中央高校自主科技创新基金”“企业横向课题”等多个科研项目，作为骨干参与国家重点研发计划2项。已在Theranostics, Journal of Agricultural and Food Chemistry（封面）,Food Chemistry, Molecular Nutrition & Food Research, Food & Function等权威期刊发表研究论文30余篇，包括28篇SCI，一作&通讯12篇。荣获“山东省高等学校科学技术一等奖”1次；申请专利3项，已公布3项（含授权1项）；参编专著4部（暂出版2部）；担任Frontiers in Microbiology (TOP期刊)评审编辑; Food& Function (TOP期刊), Journal of the Science of Food and Agriculture (TOP期刊), Food Bioscience, Frontiers in Nutrition, Fermentation, Microorganisms等SCI及同水平国际权威期刊审稿人。

教育经历

2021年6月毕业于中国海洋大学, 获食品科学博士学位

工作经历

2021.12-至今, AG真人国际, AG真人国际, 讲师

研究领域

1. 致力于有益微生物资源发掘与利用
2. 致力于有益乳酸菌相关代谢调控机制研究
3. 致力于乳品相关功能活性成分机制研究

科研项目

1. 国家自然科学基金青年基金，项目号：32202061，2023.01-2025.12，主持。
2. 湖北省青年科技人才晨光托举工程A类人才项目，主持。
3. 湖北省自然科学基金青年基金，项目号：2022CFB763，2022.06-2024.06，主持。
4. 中央高校自主科技创新基金, 项目号：2662022SPQD001，2022.01-2024.12, 主持。
5. 企业横向课题，项目号：0220230048，2023.04-2024.03, 主持。
6. 国家重点研发计划，“乳酸菌或蛋白酶水解生产特定功能乳制品产品研究与应用示范”，2576万元，项目号：2018YFC1604302，2018.12-2021.12，结题，骨干。
7. 国家重点研发计划，“恶性肿瘤姑息治疗和护理关键技术研究”，50万元，项目号：2017YFC1309200，2017.07-2020.12，结题，骨干。
8. 国家自然科学基金青年基金, “乳脂球膜组成对乳脂结构的影响及机理研究”, 项目号：31801500, 2019.01-2021.12, 结题，参与。
9. 国家自然科学基金面上项目, 项目号：32272288, 2023.01-2026.12, 在研，参与。
10. 国家自然科学基金面上项目, 项目号：32272469, 2023.01-2026.12, 在研，参与。

成果奖励

【发表论文】
1. Yuanshang Wang, Xiaoran Wang, Yi Yan, Jia Wang, Youyou Lu#, A.M. Abd El-Aty#, Xiaohong Wang. A visual colorimetric assay based on phage T156 and gold nanoparticles for the sensitive detection of Salmonella in lettuce, Analytica Chimica Acta,1272,2023,341501
2. Ziqi Li, Yanchun Shao, Yunxia Gong, Wanrong Wu, Lerui Cao, Baixue Li, Youyou Lu#. Effect of starter inoculation proportions on the attributes of a superior new variety Osmanthus glutinous rice-fermented milk beverages. International Journal of Food Science and Technology, 2023, Doi:10.1111/ijfs.16535
3. Yalin Zhang, Youyou Lu*, Fusheng Chen*. Relationship between physicochemical properties and microbial structural distribution of Chinese-style and Salami fermented sausages. Food Bioscience,2023, 53:102583
4. Yeting Wu#, Youyou Lu#, Yuhao Huang, Junyu Wang, Siyue Li, Mengyao Xu, Hong Lin, Zhenxing Li*. Comparative analysis of glycosylation affecting sensitization by regulating the cross-Reactivity of parvalbumins in turbot (Scophthalmus maximus), conger eel (Conger myriaster) and sea bass (Micropterus salmoides). Journal of Agricultural and Food Chemistry, 2022, 70(34):10611-10619（封面）
5. Youyou Lu, Xi Liang, Yeting Wu, Ruiqi Wang, Tongjie Liu, Huaxi Yi, Zhuang Yu, Zhe Zhang, Pimin Gong*, Lanwei Zhang*. Bifidobacterium animalis sup F1-7 acts as an effective activator to regulate immune response via Casepase-3 and Bak of FAS/CD95 pathway. Probiotics and Antimicrobial Proteins, 2022, Doi: 10.1007/s12602-022-09975-9
6. Youyou Lu, Zhuang Yu, Zhe Zhang, Xi Liang, Pimin Gong, Huaxi Yi, Liuqing Yang, Tongjie Liu, Hanping Shi*, Lanwei Zhang*. Bifidobacterium animalis F1-7 in combination with konjac glucomannan improves constipation in mice via humoral transport. Food & Function, 2021, 12(2):791-801
7. Youyou Lu, Zhe Zhang, Lingjun Tong, Xiaohong Zhou, Xi Liang, Huaxi Yi, Pimin Gong, Tongjie Liu, Lanwei Zhang*, Liuqing Yang, Hanping Shi*. Mechanisms underlying the promotion of 5-hydroxytryptamine secretion in enterochromaffin cells of constipation mice by Bifidobacterium and Lactobacillus. Neurogastroenterology and Motility, 2021, 33: e14082
8. Youyou Lu#, Junxue Zhang#, Xiaohong Zhou, Meiyu Guan, Zhe Zhang, Xi Liang, Lingjun Tong, Huaxi Yi, Pimin Gong, Lu Bai, Hui Zhou, Tongjie Liu*, Lanwei Zhang*. The edible Lactobacillus paracasei X11 with Konjac glucomannan promotes intestinal motility in zebrafish. Neurogastroenterology and Motility, 2021, 33: e14196
9. Youyou Lu#, Junxue Zhang#, Zhe Zhang, Xi Liang, Tongjie Liu, Huaxi Yi, Pimin Gong, Lingli Wang, Wenjun Yang, Xinyi Zhang, Lanwei Zhang*, Liuqing Yang, Hanping Shi*. Konjac glucomannan with probiotics acts as a combination laxative to relieve constipation in mice by increasing short-chain fatty acid metabolism and 5-hydroxytryptamine hormone release. Nutrition, 2021, 84:111112
10. Youyou Lu, Zhe Zhang, Xi Liang, Yujie Chen, Junxue Zhang, Huaxi Yi, Tongjie Liu, Liuqing Yang, Hanping Shi*, Lanwei Zhang*. Study of gastrointestinal tract viability and motility via modulation of serotonin in a zebrafish model by probiotics. Food & Function, 2019, 10(11):7416-7425
11. Youyou Lu, Junxue Zhang, Huaxi Yi, Zhe Zhang, Lanwei Zhang*. Screening of intestinal peristalsis-promoting probiotics based on a zebrafish model. Food & Function, 2019, 10(4):2075-2082
12. Youyou Lu, Nana Wang, Jiao He, Yanfang Li, Xiaoning Gao, Lili Huang*, Xia Yan*. Expression and characterization of a novel chitinase with antifungal activity from a rare actinomycete, Saccharothrix yanglingensis Hhs.015. Protein Expression and Purification, 2018,143:45-51
13. Yeting Wu, Youyou Lu, Yuhao Huang, Hong Lin, Guanzhi Chen, Yan Chen, Zhenxing Li*. Glycosylation reduces the allergenicity of turbot (Scophthalmus maximus) parvalbumin by regulating digestibility, cellular mediators release and Th1/Th2 immunobalance. Food Chemistry, 2022,382:132574
14. Yeting Wu, Youyou Lu, Yuhao Huang, Hong Lin, Mengyao Xu, Ishfaq Ahmed, Guanzhi Chen, Yan Chen, Zhenxing Li*. Fish allergens of turbot (Scophthalmus maximus) parvalbumin triggers food allergy via inducing maturation of bone marrow derived dendritic cell and driving Th2 immune response. Food & Function, 2022,13:4194-4204
15. Yeting Wu, Youyou Lu, Yuhao Huang, Hong Lin, Xuewen Dang, Yujie Jing, Zhaocheng Meng, Xiangchen Wang*, Zhenxing Li*. Insight analysis of the cross sensitisation of multiple fish parvalbumins via the Th1/Th2 immunological balance and cytokine release from the perspective of safe consumption of fish, Food Quality and Safety, 2022, Doi:10.1093/fqsafe/fyac056
16. Xi Liang, Youyou Lv, Zhe Zhang, Huaxi Yi, Tongjie Liu, Rui Li, Zhuang Yu, Lanwei Zhang*. Study on intestinal survival and cholesterol metabolism of probiotics. LWT-Food Science and Technology, 2020, 124: 109132
17. Xi Liang, Zhe Zhang, Youyou Lv, Haiyan Lu, Tongjie Liu, Huaxi Yi, Maozhen Zhao, Lanwei Zhang *，Pimin Gong*. Krill oil combined with Bifidobacterium animalis subsp. lactis F1-7 alleviates the atherosclerosis of ApoE-/- mice. Foods, 2021, 10, 2374
18. Zhe Zhang, Xi Liang, Youyou Lv, Huaxi Yi, Yujie Chen, Lu Bai, Hui Zhou, Tongjie Liu, Rui Li, Lanwei Zhang*. Evaluation of probiotics for improving and regulation metabolism relevant to type 2 diabetes in vitro. Journal of Functional Foods, 2020, 64:103664
19. Xi Liang, Zhe Zhang, Youyou Lv, Linjun Tong, Tongjie Liu, Huaxi Yi, Xiaohong Zhou, Zhuang Yu, Xiaoying Tian, Qingyu Cui, Jiebing Yang, Pimin Gong, Lanwei Zhang*. Reduction of intestinal trimethylamine by probiotics ameliorated lipid metabolic disorders associated with atherosclerosis. Nutrition, 2020, 79:110941
20. Yeting Wu, Hong Lin, Youyou Lu, Yuhao Huang, Binaka Prabashini Dasanayaka, Ishfaq Ahmed, Guanzhi Chen, Yan Chen, Zhenxing Li*. Allergenicity determination of Turbot parvalbumin for safety of fish allergy via dendritic cells, RBL-2H3 cell and mouse model. European Food Research and Technology, 2021,1-16
21. Lingjun Tong, Haining Hao, Zhe Zhang, Youyou Lv, Xi Liang, Qiqi Liu, Tongjie Liu, Pimin Gong, Lanwei Zhang, Fangfang Cao, Giorgia Pastorin, Chuen Neng Lee, Xiaoyuan Chen, Jiong-Wei Wang*, Huaxi Yi*. Milk-derived extracellular vesicles alleviate ulcerative colitis byregulating the gut immunity and reshaping the gut microbiota. Theranostics, 2021, 11(17): 8570-8586
22. Zhe Zhang, Xi Liang, Lingjun Tong, Youyou Lv, Huaxi Yi, Pimin Gong, XiaoyingTian, Qingyu Cui, Tongjie Liu*, Lanwei Zhang*. Effect of Inonotus obliquus (Fr.) Pilat extract on the regulation of glycolipid metabolism via PI3K/Akt and AMPK/ACC pathways in mice. Journal of Ethnopharmacology, 2021, 273:113963
23. Xi Liang, Zhe Zhang, Xiaohong Zhou, Youyou Lu, Rui Li, Zhuang Yu, Lingjun Tong, Pimin Gong, Huaxi Yi, Tongjie Liu*, Lanwei Zhang*. Probiotics improved hyperlipidemia in mice induced by a high cholesterol diet via downregulating FXR. Food & Function, 2020, 11(11):9903-9911
24. Zhe Zhang, Hui Zhou, Lu Bai, Youyou Lv, Huaxi Yi, Lanwei Zhang*, Rui Li*. Protective effects of probiotics on acute alcohol-induced liver injury in mice through alcohol metabolizing enzymes activation and hepatic TNF-α response reduction. Journal of Functional Foods, 2019, 59:234-241
25. Lingjun Tong, Haining Hao, Xinyi Zhang, Zhe Zhang, Youyou Lv, Lanwei Zhang, Huaxi Yi*. Oral administration of bovine milk-derived extracellular vesicles alters the gut microbiota and enhances intestinal immunity in mice. Molecular Nutrition & Food Research, 2020, 64(8):1901251（封面）
26. Zhe Zhang#, Hui Zhou#, Meiyu Guan, Xiaohong Zhou, Xi Liang, Youyou Lv, Lu Bai, Junxue Zhang, Pimin Gong, Tongjie Liu, Huaxi Yi, Jingfeng Wang, Lanwei Zhang*. Lactobacillus casei YRL577 combined with plant extracts reduce markers of non-alcoholic fatty liver disease in mice. British Journal of Nutrition, 2020, 28:1-11
27. Zhe Zhang#, Hui Zhou#, Xiaohong Zhou, Jize Sun, Xi Liang, Youyou Lv, Lu Bai, Junxue Zhang, Pimin Gong, Tongjie Liu, Huaxi Yi, Jingfeng Wang, Lanwei Zhang*. Lactobacillus casei YRL577 ameliorates markers of non-alcoholic fatty liver and alters expression of genes within the intestinal bile acid pathway. British Journal of Nutrition, 2021, 125(5):521-529
28. Zhe Zhang#, Lu Bai#, Meiyu Guan, Xiaohong Zhou, Xi Liang, Youyou Lv, Huaxi Yi, Hui Zhou, Tongjie Liu*, Pimin Gong, Jize Sun*, Lanwei Zhang*. Potential probiotics Lactobacillus casei K11 combined with plant extracts reduce markers of type 2 diabetes mellitus in mice. Journal of Applied Microbiology, 2021, 131, 1970-1982
【申报专利】
1. 张兰威，吕优优，公丕民，刘同杰，易华西，张喆，梁曦。一株促肠蠕动动物双歧杆菌亚种F1-7及应用。（授权号CN 113564067 B）
2. 公丕民，吕优优，张兰威，刘同杰，易华西，张喆，梁曦。一株副干酪乳杆菌X11及其组合物便秘复合制剂及乳制品。（公布号CN 112694989 A）
3. 张兰威，吕优优，公丕民，刘同杰，易华西，张喆，梁曦。一株动物双歧杆菌F1-7、组合物、粪便干结复合制剂及果乳制品。（公布号CN 113186113 A）
【已出版的参编专著】
1. 《肿瘤代谢学》/石汉平等主编.北京:科学出版社，2023.03，ISBN 9787030737373
2. 《肿瘤微生态学》/石汉平等主编.北京:科学出版社，2021.06，ISBN 9787030691347
【荣誉奖励】 1. “扬翔杯”第十届肉制品加工（预制食品）创意大赛一等奖（迟晨鸣等），第一指导教师，2023；
2. 食品安全与营养中国行（2023）食育校园初赛（知识宣讲大赛）一等奖（杜飞燕等），第一指导教师，2023；
3. 食品安全与营养中国行（2023）食育校园初赛（知识宣讲大赛）二等奖（林爽等），第一指导教师，2023；
4. 食品安全与营养中国行（2023）食育校园初赛（知识宣讲大赛）三等奖（迟晨鸣等），第一指导教师，2023；
5. 中国食品科学技术学会第一届“飞鹤杯”乳制品创新竞赛优秀作品奖（迟晨鸣等），共同指导教师，2022；
6. 湖北省第五届老员工酸奶DIY创新竞赛省级前4强（罗依婷等），共同指导教师，2022；
7. AG真人国际第五届老员工酸奶DIY创新竞赛十佳作品奖（苏雯静等），第一指导教师，2022；
8. AG真人国际第五届老员工酸奶DIY创新竞赛十佳作品奖（袁懿然等），第一指导教师，2022；
9. AG真人国际第五届老员工酸奶DIY创新竞赛十佳作品奖（窦化鹏等），第一指导教师，2022；
10. AG真人国际第五届老员工酸奶DIY创新竞赛优秀作品奖（迟红婷等），第一指导教师，2022；
11. “AG真人国际暑期社会实践活动优秀指导教师”，2022；
12. “第十六届益生菌与健康国际研讨会优秀论文奖”，2021；
13. “山东省高等学校科学技术奖一等奖”—（益生乳酸菌定向筛选及其高活性产品开发的关键技术），2020；
【学术兼职】
受邀担任《Frontiers in Microbiology》(TOP期刊)评审编辑；《Food& Function》(TOP期刊)《Journal of the Science of Food and Agriculture》(TOP期刊)《Food Bioscience》《Frontiers in Nutrition》《Fermentation》《Microorganisms》等SCI及同水平国际学术期刊审稿人。

团队力量