个人简介

王小红，女，AG真人国际教授，博士，博士生导师。中国微生物学会会员，湖北省暨武汉市微生物学会真菌专业委员会任常务委员，湖北省食品安全专家委员会专家，国家科技管理信息系统专家库评审专家。长期致力于食品安全检测与控制的基础理论与关键技术的研究，在常见食源性病原微生物的检测与控制、真菌毒素的免疫学检测等研究领域取得了多项创新性的研究成果，主持承担包括国家“食品安全关键技术研发”重点专项、863计划、国家自然科学基金、湖北省公益性行业、湖北省重点研发计划等项目在内的国家及省部级课题10多项，发表研究论文60余篇（SCI），副主编国家“十一五”规划教材1本，获得授权发明专利6项，获湖北省科技进步二等奖1项，湖北省技术发明奖二等奖1项。

教育经历

1.2001/9–2005/6， AG真人国际，攻读博士学位，专业：农产品贮藏与加工，导师：谢笔钧教授
2.1994/9–1997/6，AG真人国际，攻读硕士学位，专业：农产品贮藏与加工，导师：谢笔钧教授
3.1987/9–1991/6， AG真人国际，食品科学，工学学士

工作经历

1. 1991/7-1994/8，助理工程师，武汉市食品工业公司科研所任职，从事新产品开发与研究。
2. 1997/7-至今，在AG真人国际从事教学和科研工作。
3. 2010/10-2011/10，美国加州大学戴维斯分校化学系，国家留学基委公派，访问学者，合作导师：Prof. Claude Meares
4. 2019/11-12，美国康奈尔大学食品科学系，国家留学基委公派，高级访问学者，合作导师：Prof. Sam R. Nugen

研究领域

长期致力于食品安全检测与控制的基础理论与关键技术的研究，以导致食品安全的常见食源性病原微生物、真菌毒素等生物危害因子为研究对象，重点针对其检测与控制中的关键识别元件、控制机理及检测关键技术等展开深入研究。主要研究方向：1. 基于噬菌体及其编码蛋白的食源性病原微生物的检测与控制研究；2. 肉制品中有害微生物的检测与控制研究；3.农产品中常见真菌毒素的免疫学检测技术研究

科研项目

1. 国家重点研发计划课题，2017YFC1600105，食源性致病菌耐药性动态数据库及控制技术的建立，2018.1-2021.12，主持
2. 国家重点研发计划子课题，2019YFC1606001，小龙虾全链条生物危害物精准识别与检测技术，2019.12-2022.12，主持
3. 国家自然科学基金面上项目，31772054，噬菌体受体结合蛋白功能结构域介导的沙门氏菌快速检测的分子机制研究，2018.1-2021.12，主持
4. 国家自然科学基金面上项目，31271876，抗黄曲霉毒素B1高亲和力抗体的分子机理研究及改造， 2013.1-2016.12，主持
5. 国家自然科学基金面上项目，30871754，抗AFB1抗独特型抗体反应历程的现代仪器表征，2009.1-2011.12，主持
6. 国家高技术研究发展计划（863计划），2008AA10Z4，农产品中重要真菌毒素抗体芯片检测技术研究，2008.1-2010.12，主持
7. 国家高技术研究发展计划（863计划）子课题，2012AA101600，华中地区食源性致病微生物的检测鉴定与毒力评价，2012.1-2015.12，主持
8. 湖北省重点研发计划子课题，2022BBA0057-02，淡水水产品中危害因子分子识别元件的研发，2022.7-2024.12，主持
9. 湖北省公益性行业项目，2014BBB016，蔬菜内化污染病原菌的分离、分子分型与检测控制技术研究，2014.1-2016.12，主持
10. 湖北省科技攻关计划，2007AA204A，米酒加工技术研究与产业化开发，2007.1-2009.12, 主持
11. 上海市科技创新行动计划，0839191100，食源性致病微生物快速检测关键技术的研究及溯源管理， 2008.1-2010.12, 主持
12. 广东省教育部产学研结合项目，2009B09030，药用橄榄深加工技术开发与产业化示范，2009.1-2011.12，主持
13. 中央高校基本科研业务费专项资金项目，2013PY103，粮食作物中真菌毒素预警指标体系的研究，2013.1-2015.12, 主持

成果奖励

（科研获奖）
1. 食品中典型危害因子的磁-光-电快速检测技术及装备创制，2022，湖北省技术发明奖二等奖，排名第2；
2. 现代生物技术在食品安全快速检测技术中的应用及其相关仪器设备的研制，2012，湖北省科技进步奖二等奖，排名第3；
3. 食品中沙门菌和志贺氏菌的双重LAMP检测技术研究，2013，武汉市科技进步二等奖，排名第3 （代表性论文）
1. Yifeng Ding, Chenxi Huang, Yiming Zhang, Jia Wang, Xiaohong Wang*. Magnetic microbead enzyme-linked immunoassay based on phage encoded protein RBP 41-mediated for rapid and sensitive detection of Salmonella in food matrices. Food Research International 163 (2023) 112212
2. Chenxi Huang, Ranjing Zheng, Yifeng Ding, Sam R. Nugen, Xiaohong Wang*. Dual phage amplification-mediated multiplex detection strategies for the simultaneous detection of Salmonella enterica and Staphylococcus aureus. Talanta 253 (2023) 124095
3. Chenxi Huang, Junpeng Zhao, Rongsheng Lu, Jia Wang, Sam R. Nugen, Yiping Chen*, Xiaohong Wang*. A phage-based magnetic relaxation switching biosensor using bioorthogonal reaction signal amplification for Salmonella detection in foods. Food Chemistry 400 (2023) 134035
4. Yifeng Ding, Chenxi Huang, Muxiao Chen, Jia Wang, Yanchun Shao, Xiaohong Wang*. Rapid and simultaneous detection of viable S. aureus and its penicillin susceptibility by phage amplification techniques in different food matrices. LWT - Food Science and Technology 176 (2023) 114526
5. Yifeng Ding, Chenxi Huang, Wenjuan Zhu, Zhiwei Li, Yu Zhang, Jia Wang, Hui Pan, Huihui Li*, Xiaohong Wang*. Characterization of a novel Jerseyvirus phage T102 and its inhibition effect on biofilms of multidrug-resistant Salmonella. Virus Research 326 (2023) 199054
6. Ji Wang#, Huihui Li#, Changbin Li, Yifeng Ding, Yuanshang Wang, Wenjuan Zhu, Jia Wang, Yanchun Shao, Hui Pan, Xiaohong Wang*. EIS biosensor based on a novel Myoviridae bacteriophage SEP37 for rapid and specific detection of Salmonella in food matrixes. Food Research International 158 (2022) 111479
7. Wenjuan Zhu, Yifeng Ding, Chenxi Huang, Ji Wang, Jia Wang, Xiaohong Wang*. Genomic characterization of a novel bacteriophage STP55 revealed its prominent capacity in disrupting the dual‑species biofilm formed by Salmonella Typhimurium and Escherichia coli O157: H7 strains. Archives of Microbiology (2022) 204:597
8. Changbin Li, Yuanshang Wang, Jia Wang, Xiaohong Wang*. Properties of a novel Salmonella phage L66 and its application based on electrochemical sensor-combined AuNPs to detect Salmonella. Foods, 2022, 11, 2836
8.王吉，李慧慧，朱文娟，王佳，王小红*. 基于噬菌体的电化员工物传感器在检测食源性病原菌中的研究进展. 食品科学，2022, 43(7): 254-262
9. Xiaoxiao Guo, Fusheng Chen , Jiao Liu, Yanchun Shao, Xiaohong Wang*, Youxiang Zhou*. Genome Mining and Analysis of PKS Genes in Eurotium cristatum E1 Isolated from Fuzhuan Brick Tea. J. Fungi 2022, 8, 193.
10. Zhiwei Li, Wanning Li, Wenjuan Ma, Yifeng Ding, Yu Zhang, Qile Yang, Jia Wang, Xiaohong Wang*. Characterization and application of lytic phage D10 against multidrug-resistant Salmonella，Viruses 2021, 13, 1626
11. Chenxi Huang, Binti Youssouf Mahboubat, Yifeng Ding, Qile Yang, Jia Wang, Min Zhou, Xiaohong Wang*. Development of a rapid Salmonella detection method via phage-conjugated magnetic bead separation coupled with real-time PCR quantification. LWT- Food Science and Technology, 2021,142: 111075
12. Junjie Li, Yameng Li, Yifeng Ding, Chenxi Huang, Yu Zhang, Jia Wang, Xiaohong Wang*. Characterization of a novel Siphoviridae Salmonella bacteriophage T156 and its microencapsulation application in food matrix. Food Research International, 2021,140: 110004
13. Yu Zhang, Yifeng Ding, Wanning Li, Wenjuan Zhu, Jia Wang, Xiaohong Wang*. Application of a novel lytic Podoviridae phage Pu20 for biological control of drug-resistant Salmonella in liquid eggs. Pathogens, 2021, 10(1):34
14. Xiaoqing Hu *, Xiaoying Sun, Shuanghua Luo, Shuyan Wu, Zhaojuan Chu, Xiujuan Zhang, Zhaojun Liu, Jiaxin Wu, Xiaohong Wang*, Chang Liu, Xiaoyuan Wang. Inactivation of Salmonella enterica Serovar Enteritidis on Chicken Eggshells Using Blue Light. Agriculture 2021, 11(8), 762;
15. Weifeng Chen, Zhiwei Li, Xingxing Dong, Xiaohong Wang*. A tetravalent single-chain variable fragment antibody for the detection of staphylococcal enterotoxin A. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) 2021，22(4):305-309
16.丁一峰，聂若男，朱文娟，王吉，王佳，王小红*. 沙门菌噬菌体 T139 基因组分析及其裂解酶 LysT40 的异源表达和活性鉴定. AG真人国际学报, 2021, 40(6):10-19
17. 杨其乐, 丁一峰, 张宇, 聂若男, 李亚萌, 王佳, 王小红*. 沙门氏菌噬菌体LPST144尾纤维gp38 的序列分析及其结合活性研究. 食品科学，2021，42（2）：66-73
18. Zhiwei Li, Wenjuan Ma, Wanning Li, Yifeng Ding, Yu Zhang, Qile Yang, Jia Wang, Xiaohong Wang*. A broad-spectrum phage controls multidrug-resistant Salmonella in liquid eggs. Food Research International, 2020, 132: 1873-7145
19. Yifeng Ding, Yu Zhang, Chenxi Huang, Jia Wang, Xiaohong Wang*. An endolysin LysSE24 by bacteriophage LPSE1 confers specific bactericidal activity against multidrug resistant Salmonella strains. Microorganisms 2020, 8, 737
20. Aiping Liu,†, Yuping Wang,†, Xingzhe Cai, Shan Jiang, Xiaowen Cai, Li Shen, Yuntao Liu, Guoquan Han, Shujuan Chen, Jia Wang, Wenjuan Wu, Cheng Li, Shuliang Liu, Xiaohong Wang*. Characterization of endolysins from bacteriophage LPST10 and evaluation of their potential for controlling Salmonella Typhimurium on lettuce. LWT - Food Science & Technology 114 (2019) 108372
21. Jia Wang, Hina Mukhtar, Lan Ma, Qian Pang and Xiaohong Wang*. VHH antibodies: reagents for mycotoxin detection in food products. Sensors, 2018, 18, 485
22. Aiping Liu∗, Li Shen, Zhenghai Zeng, Min Sun, Yuntao Liu, Shuliang Liu, Cheng Li, Xiaohong Wang∗. A minireview of the methods for Listeria monocytogenes detection. Food Anal. Methods, 2018, 11:215-223
23. Chenxi Huang, Jianchun Shi, Wenjuan Ma, Zhi Li, Jia Wang, Jinquan Li, Xiaohong Wang*. Isolation, characterization, and application of a novel specific Salmonella bacteriophage in different food matrices. Food Research International, 2018, 111, 631-641
24. Li Hu, Aiping Li, Weifeng Chen，Hongxiu Yang, Xiaohong Wang*, Fusheng Chen*. A non-toxic enzyme-linked immunosorbent assay for aflatoxin B1 using anti-idiotypic antibodies as substitutes，Journal of the Science of Food & Agriculture, 2017,97(5):1543-1548
25. Aiping Liu, Yang Ye, Xiaohong Wang*, Fusheng Chen*. Spectra analysis of coating antigen: a possible explanation for difference in anti-AFB1 polyclonal antibody sensitivity. Journal of Molecular Structure, 2016, 1121:74-79
26. Weifeng Chen, Yucui Jin, Aiping Liu, Xiaohong Wang*, Fusheng Chen*. Rapid detection of ochratoxin A on membrane by dot-immunogold filtration assay. Journal of the Science of Food and Agriculture, 2016,96(2):610-614
27. Aiping Liu, Yang Ye, Weifeng Chen, Xiaohong Wang*, Fusheng Chen*. Expression of VH-Linker-VL orientation-dependent single chain Fv antibody fragment derived from hybridoma 2E6 against aflatoxin B1 in Escherichia coli. Journal of Industrial Microbiology & Biotechnology, 2015, 42(2): 255-265
28. Wanping Chen, Xiaohong Wang*, Fusheng Chen*. Characterization of nine traditional Chinese plant extracts with specific acid dissociation constants by UV-Vis spectrophotometry. Analytical Methods.2014,6(2):581-588
29. Xiuyan Zhang, Xiaoyan Hou, Fang Liang, Fusheng Chen, Xiaohong Wang*. Surface display of malolactic enzyme from Oenococcus oeni on Saccharomyces cerevisiae. Applied Biochemistry and Biotechnology,2013(169):2350-2361
30. Aiping Liu, Yongxia Zhang, Weifeng Chen, Fusheng Chen*, Xiaohong Wang*. Gold nanoparticle-based colorimetric detection of staphylococcal enterotoxin B using ssDNA aptamer. European food research & technology, 2013,237(3): 323-329
31. Youxiang Zhou, Jianbiao Chen, Lina Dong, Liang Lu, Fusheng Chen, Dingjin Hu, Xiaohong Wang*. A study of ﬂuorescence properties of citrinin in b-cyclodextrin aqueous solution and different solvents. Journal of Luminescence, 2012, 132(6):1437-1445
32. Aiping Liu, Hongxiu Yang, Xiaohong Wang*, Fusheng Chen*. Spectral characteristics of fluorescence and circular dichroism of aflatoxin B1 reaction with its anti-idiotypic antibody. Journal of Molecular Structure, 2012,1028: 73-78
（第一发明人授权发明专利）
都柏林沙门氏菌噬菌体D1-2及其在液蛋样品中的应用 (ZL 2019 1 0456707.6)
鸡白痢沙门氏菌噬菌体Pu20及其在液蛋中的应用 (ZL 2019 1 0456689.1)
沙门氏菌噬菌体纳米磁珠偶联物及其富集分离试剂盒 (ZL 2019 1 0158850.7)
沙门氏菌噬菌体LPST144以及其裂解酶的抗菌应用 (ZL 2020 1 0036628.2)
金黄色葡萄球菌噬菌体LSA2311及其应用研究 (ZL 2020 1 1210849.3)
鼠伤寒沙门氏菌噬菌体T156及其微囊化应用 (ZL 2020 1 0712852.9)

其它

作为副主编出版《食品安全实验-检测技术与方法》国家“十一五”规划教材一部。主持完成成果鉴定3项，参与完成鉴定成果7项。曾获AG真人国际教学成果二等奖、教学质量优秀奖、湖北省优秀学士学位论文指导教师、老员工国家创新性实验计划指导教师等多项荣誉或称号。招收研究生专业 1. 食品加工与安全 2. 食品科学 3. 食品营养与安全